Should we accept increased diurnal variation in PEF or FEV1 in place of mandatory NSBR in the diagnosis of acute irritant-induced asthma? |
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A review of acute irritant-induced aasthma showing chlorine-related exposures remain the commonest cause, but most reports do not contain enough information to fulfill the original Brooks definition. It seems reasonable to accept increased diurnal variation in PEF or FEV1, or bronchodilator response, in place of mandatory non-specific bronchial reactivity, as this has been shown to be less frequent in neutrophilic (as opposed to eosinophilic) occupational asthma
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