Occupational rhinitis due to sodium alendronate (new cause)

Agent	Sodium alendronate
Job	Tablet packer in pharmaceutical plant
Specific IgE	not done
Lymphocyte proliferation	not tested
Skin prick test	positive 1:10 w/v
Patch test	positive 1:10 w/v
Non-specific reactivity	Methacholine Pc20 1636 u/ml pre challenge and 704 ug/ml post challenge
Serial Peak Flow	not done
Induced sputum	Eosinophils 1.2% pre and 7.9% post alendronate challenge
Specific Challenge	10mg alendronate in lactose for 60 minutes positive immediate nasal reaction but no chande in FEV1
Follow-up	symptom free after removal from exposure

References

	Pala G, Perfetti L, Cappelli I, Caminati M, Moscato G, Occupational rhinitis to sodium alendronate, Allergy, 2008;63:1092-1093,

Comments