Occupational Asthma Reference
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Pala G, Perfetti L, Cappelli I, Caminati M, Moscato G,
Occupational rhinitis to sodium alendronate,
Allergy,
2008;63:1092-1093,
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Keywords: rhinitis, challenge, skin prick test, bronchial reactivity, patch test, alendronate, pharmaceutical worker
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Abstract
Agent Sodium alendronate
Job Tablet packer in pharmaceutical plant
Specific IgE not done
Lymphocyte proliferation not tested
Skin prick test positive 1:10 w/v
Patch test positive 1:10 w/v
Non-specific reactivity Methacholine Pc20 1636 u/ml pre challenge and 704 ug/ml post challenge
Serial Peak Flow not done
Induced sputum Eosinophils 1.2% pre and 7.9% post alendronate challenge
Specific Challenge 10mg alendronate in lactose for 60 minutes positive immediate nasal reaction but no chande in FEV1
Follow-up symptom free after removal from exposure
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Comments
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Although the challenge test did not show a decline in FEV1, the symptoms and changes in NSBR suggest that there might have been an asthmatic element to the disease. Serial PEF at work would have helped to establish or refute this
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