Occupational Asthma Reference

Barber CM, Burton CM, Scaife H, Crook B, Evans GS, Systematic review of respiratory case definitions in metalworking fluid outbreaks, Occup Med, 2012;62:337-342,


Known Authors

Chris Barber, Health and Safety Laboratories, Buxton Chris Barber

Gareth Evans, HSL, Buxton Gareth Evans

Clare Burton, Sheffield University and HSL Buxton Clare Burton

If you would like to become a known author and have your picture displayed along with your papers then please get in touch from the contact page. Known authors can choose to receive emails when their papers receive comments.


Since the mid-1990s, outbreaks of asthma and extrinsic allergic alveolitis (EAA) have been identified in workers exposed to metalworking fluids (MWFs). The cause of these outbreaks remains to be determined.

To identify and review all previously published occupational lung disease case definitions and diagnostic criteria that have been utilized during MWF outbreak investigations.

Respiratory outbreaks due to MWFs were identified by a systematic literature search for articles published between 1990 and October 2011. Investigations reporting the usage of disease case definitions or diagnostic criteria for respiratory disease were reviewed and summarized.

The literature search identified 35 papers relating to 27 outbreaks of respiratory disease in MWF-exposed workers. Fourteen case definitions for MWF-related respiratory disease were identified: seven for EAA, five for occupational asthma and one each for humidifier fever and industrial bronchitis. A single paper was identified where any comparison of different disease case definitions (for EAA) had been performed.

A range of case definitions and diagnostic criteria for MWF respiratory disease have been utilized in outbreak investigations, but the majority have been produced for individual outbreak investigations without previous validation. It may be difficult to compare the findings of future workplace studies without a more standardized approach to case identification and diagnosis.

Full Text


Please sign in or register to add your thoughts.

Oasys and occupational asthma smoke logo