Occupational Asthma Reference

Bernstein DI, Kissling GE, Hershey GK, Yucesoy B, Johnson VJ, Cartier A, Gautrin D, Sastre J, Boulet L, Malo J, Quirce S, Tarlo SM, Langmeyer S, Luster MI, Lummus ZL, Hexamethylene diisocyanate asthma is associated with genetic polymorphisms of CD14, IL-13, and IL-4 receptor a, J Allergy Clin Immunol, 2011;128:418-420,

Keywords: HDI, isocyanate, HLA, genetics

Known Authors

André Cartier	Joaquin Sastre	Jean-Luc Malo	David Bernstein	Denise Gautrin
Zana Lummus	Santiago Quirce	Susan Tarlo

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Abstract

we have confirmed a previous observation in expanded groups of workers: a reported association between genotype combinations associated with Th2 and innate immunity and diisocyanate-induced asthma caused by HDI. Replication of these results in other background populations will be necessary to define the possible value of these genetic markers for risk assessment.

Full Text

http://www.jacionline.org/article/S0091-6749(11)00423-4/fulltext

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