Occupational Asthma Reference

Quirce S, Pelta R, Sastre J, Occupational asthma due to piperazine citrate., J Inv Allergod Clin Immunol, 2006;16:138-139,

Keywords: challenge, piperazine, spain, case report, chemical processor, rhinitis, asthma, skin prick test, challenge, NSBR

Known Authors

Joaquin Sastre, Fundacion Jimenez Diaz, Madrid Joaquin Sastre

Santiago Quirce, Madrid Santiago Quirce

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BACKGROUND: Piperazine is a secondary heterocyclic amine that may give rise to occupational asthma of uncertain mechanism.

METHODS: We report on a 42-year-old woman, a process operator in a chemical factory, who developed work-related symptoms of rhinitis and asthma upon exposure to piperazine citrate. She remained symptom free during holidays and days off work.

RESULTS: Skin prick test with piperazine citrate was positive. Specific inhalation challenge with piperazine citrate at a concentration of 5 mg/m3 for 30 minutes elicited an isolated late asthmatic response. Airway hyperresponsiveness to methacholine significantly increased 3 hours after the piperazine challenge, preceding the late asthmatic response.

CONCLUSION: This patient had developed occupational asthma caused by piperazine, as confirmed by the specific inhalation challenge test, possibly due to an immunological mechanism.

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