Oasys plots and challenge tests show concordant results

A review of all patients with a positive challenge test to occupational agents over the last 10 years showed that the timing of immediate and late reactions during challenge tests corelated well with the timings in the workplace assessed by serial PEF measurements analysed by the Oasys ABC plot. Those with dual challenge reactions did not often have early deterioration at work and delayed recovery after leaving work, but behaved more like those with immediate or late reactions during challenge testing. The concordance of the timing of reactions in the laboratory and measured by Oasys at work provides further reassurance for the validity of both methods. Many of the challenges were with unusual agents whose mechanism of action is unclear, but all had a latent interval from first workplace exposure to the onset of symptoms, and regular symptomatic deterioration with workplace exposures.

References

	Burge PS, Moore VC, Robertson AS, Walters GI, Do laboratory challenge tests for occupational asthma represent what happens in the workplace?, Eur Respir J, 2018;51:1800059,10.1183/13993003.00059-2018

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