Reference

Renstrom A, Malmberg P, Larsson K et al, Prospective study of laboratory animal allergy: factors predisposing to sensitisation and development of allergic symptoms, Allergy, 1994;49:548-552,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

In a prospective study of laboratory technicians, selected indicators of allergy and atopy were studied in an attempt to determine predictors of laboratory-animal allergy (LAA). From results it does not seem likely that refusing to employ atopic subjects in animal work will prevent the development of LAA. Preventing atopic subjects from animal work would only have reduced the 9 sensitised and/or symptomatic subjects to 7. Preventing subjects with total IgE levels >100 kU/l from working with animals would have reduced the number of subjects developing LAA to 2 instead of 9. On the other hand, 8 non-reactive subjects (after this study) would also have been excluded from such work.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

The positive predictive values of screening criteria are too poorly discriminating for screening out potentially susceptible individuals, particularly in the case of atopy where the trait is highly prevalent.

Non Bohrf Information

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