Reference

Merget R, Dierkes A, Rueckmann A, Bergmann EM, SchultzeWerninghaus G, Absence Of Relationship Between Degree Of Nonspecific And Specific Bronchial Responsiveness In Occupational Asthma Due To Platinum Salts, Eur Respir J, 1996;9:211-216,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Study aimed to assess the quantitative association of bronchial responsiveness to methacholine (MCh) and platinum salts (Pt) in workers with Pt-induced occupational asthma. 57 subjects with Pt-induced asthma underwent skin prick tests with Pt and bronchial challenge with MCh. 5/57 had normal bronchial responsiveness (BHR) in platinum asthma (12%). There was no univariate correlation between BHR to MCh and Pt, but there was a correlation between skin reactivity to Pt and BHR to Pt. Authors conclude that there is moderate association between BHR to Pt and skin reactivity to Pt. There is no association between methacholine responsiveness and BHR to allergen in Pt-induced occupational asthma.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

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A large number of concordant studies from different centres using different methodologies demonstrated that increased non-specific reactivity is often found in workers with occupational asthma. There are however many reports of normal methacholine or histamine reactivity within 24 hours of exposure in workers with confirmed occupational asthma.

Skin prick tests are highly sensitive but less specific for occupational asthma caused by complex platinum salts.

Non Bohrf Information

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