Occupational Asthma Reference
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Ando M, Konishi K, Yoneda R, Tamura M,
Difference in the phenotypes of bronchoalveolar lavage lymphocytes in patients with summer-type hypersensitivity pneumonitis, farmer's lung, ventilation pneumonitis, and bird fancier's lung: Report of a nationwide epidemiologic study in Japan,
J Allergy Clin Immunol,
1991;87:1002-1009,10.1016/0091-6749(91)90423
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Keywords: Japan, HP, EAA, BAL
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Abstract
We performed a nationwide epidemiologic study of hypersensitivity pneumonitis (HP) in Japan by questionnaire and found that 835 cases of HP were recognized during the 1980s; 74.4% were summer-type HP, 8.1% farmer's lung, 4.3% ventilation pneumonitis, 4.1% bird fancier's lung, 2.3% other types, such as chemical worker's lung, and 6.8% of unknown causative agent. It was found that the ratios of bronchoalveolar lavage (BAL) lymphocytes were significantly different with the type of disease. The ratio was 0.6 ± 0.1 (mean ± SEM) in summer-type HP (N = 271), 4.4 ± 0.7 in farmer's lung (N = 22), 1.6 ± 0.3 in ventilation pneumonitis (N = 19), and 2.0 ± 0.5 in bird fancier's lung (N = 19). In farmer's lung, the ratio in smokers was 6.2 ± 1.9 (N = 6) in contrast with 3.4 ± 0.7 for nonsmokers (N = 16) (p < 0.05). It has been generally considered that the phenotypes of BAL lymphocytes in patients with HP are predominately CD8 cells. Our present results, however, indicate that the phenotypes of BAL lymphocytes vary with the type of HP, probably depending on factors such as causative agent, smoking, or staging of the disease.
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