Occupational Asthma Reference

de Jong K, Boezen H M, Kromhout H, Vermeulen R, Postma,D S, Vonk J M, The LifeLines Cohort study, Pesticides and other occupational exposures are associated with airway obstruction: the LifeLines cohort study, Occup Environ Med, 2014;71:88-96,

Keywords: Holland, pesticide

Known Authors

Dirkje Postma, Groningen University Dirkje Postma

If you would like to become a known author and have your picture displayed along with your papers then please get in touch from the contact page. Known authors can choose to receive emails when their papers receive comments.

Abstract

Objectives Occupational exposures are important and possibly modifiable contributors to the global burden of chronic obstructive pulmonary disease (COPD). Exposure to vapours, gases, dusts and fumes (VGDF) has been associated with a two- to threefold higher COPD risk. Less is known about effects of occupational exposure to pesticides and solvents. In the current study, we assessed if VGDF, pesticides and solvents are associated with the level of lung function and the prevalence of airway obstruction in the general population.Methods We included 11 851 subjects aged 18–89 years from the LifeLines cohort study. Regression models assessing associations between occupational exposures (no/low/high), level of lung function (prebronchodilator FEV1, FEV1/FVC) and mild and moderate/severe airway obstruction were adjusted for sex, age, height, weight, current/ex-smoking and packyears. Additionally, we stratified by smoking status and gender and tested for interaction. A second general population cohort (n=2364) was used to verify our initial findings.Results Occupational exposure to VGDF and pesticides was associated with a lower level of FEV1 and FEV1/FVC and with a higher prevalence of mild and moderate/severe airway obstruction in the two general populations investigated. There were no associations with exposure to solvents.Conclusions Occupational exposure to both VGDF and pesticides is associated with airway obstruction in the general population.

Full Text

Full text of this reference not available

Please Log In or Register to add the full text to this reference

Comments

Please sign in or register to add your thoughts.


Oasys and occupational asthma smoke logo