Occupational Asthma Reference
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Okano M, Nomura M, Hata S, Okada N, Sato K, Kitano Y, Tashiro M, Yoshimoto Y, Hama R, Aoki T,
Anaphylactic Symptoms due to Chlorhexidine Gluconate,
Acta Dermatol,
1989;125:50-52,
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Keywords: chlorhexidine, anaphylaxis, urticaria, asthma, skin test, non-occupational,
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Abstract
Six patients who developed urticaria, dyspnea, and anaphylactic shock due to topical application of chlorhexidine gluconate solution are described. Chlorhexidine gluconate was confirmed as the causative agent of type I hypersensitivity by intradermal, scratch, and epicutaneous tests. To prevent life-threatening adverse reactions, it seems important to use chlorhexidine gluconate on wound surfaces at a concentration of 0.05%, as recommended by the manufacturer; chlorhexidine gluconate may not be suitable for application to mucous membranes.
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