Occupational Asthma Reference
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Suzukawa M, Komiya A, Koketsu R, Kawakami A, Kimura M,
Three Cases of Ortho-phthalaldehydeinduced Anaphylaxis after Laryngoscopy: Detection of Specific IgE in Serum,
Allergology International,
2007;56:313-316,
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Keywords: basophils, ELISA, histamine release, IgE-mediated anaphylaxis, skin test, OPA, ortho-phthaldehydde
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Abstract
Background:
Ortho-phthalaldehyde (OPA) has recently been used as a disinfectant for various medical apparatuses. OPA is not generally recognized as a potential allergen.
Case Summary:
Subsequent to our recent report describing a patient presenting with OPA-induced anaphylaxis following laryngoscopy, we experienced two more such cases. In all three cases, the basophil histamine release test was useful for identifying the allergen as OPA. OPA-specific IgE was successfully detected in the serum of the patients by ELISA.
Discussion: Physicians and co-medical workers need to be aware of potential allergens to which patients may be exposed during routine medical procedures.
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