Occupational Asthma Reference
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Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO, Olin A, Plummer AL, Taylor DR,
Interpretation of Exhaled Nitric Oxide Levels (FENO)for Clinical Applications,
Am J Respir Crit Care Med,
2011;184:602-615,
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Keywords: guideline, review, nitric oxide, NO, FeNO, ATS
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Abstract
We suggest using the following values to determine a significant increase in FENO: greater than 20% for values over 50 ppb or more than 10 ppb for values lower than 50 ppb from one visit to the next (weak recommendation, low quality of evidence).
We suggest using a reduction of at least 20% in FENO for values over 50 ppb or more than 10 ppb for values lower than 50 ppb as the cut point to indicate a significant response to antiinflammatory therapy (weak recommendation, low quality of evidence).
Minimally Important Differences, and Prognostic Significance of FENO
The within-subject coefficient of variation for FENO in healthy subjects is approximately 10%, or up to 4 ppb. The variation increases to approximately 20%in patients with asthma. Since a change of 20% could be due to the variation in the FENO measurement, the Committee recommends a change of at least 20% to indicate a significant rise or fall in FENO over time or following an intervention.
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