Occupational Asthma Reference
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Merget R, Sander I, van Kampen V, Raulf-Heimsoth M, Ulmer H, Kulzer R, Bruening T,
Occupational immediate-type asthma and rhinitis due to rhodium salts,
Am J Ind Med,
2010;53:42-46,
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Keywords: new cause, germany, rhodium, electroplater, rhinitis, occupational asthma, case report, skin prick test, challenge, platinum
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Abstract
Background
Whereas platinum salts are well known occupational allergens, rhodium salts have not been identified as inhalative sensitizing substances.
Methods
A 27-year-old atopic operator of an electroplating plant developed work-related shortness of breath and runny nose with sneezing after exposure to rhodium salts. Quantitative skin prick tests (SPT) and bronchial challenge tests with a dosimeter protocol were performed with quadrupling doses of the sodium chloride salts of rhodium (Na3RhCl6) and platinum (Na2PtCl6).
Results
The patient showed positive SPT reactions and positive bronchial immediate-type reactions with rhodium and platinum salts. Sensitivity to rhodium salt was much higher than to platinum salt; the molar concentrations differed by a factor of 256 in SPT and a factor of 16 in bronchial challenges.
Conclusions
Rhodium salts should be considered as occupational immediate-type allergens.
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