Occupational Asthma Reference
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Campo P, Aranda A, Palacin A, Montañez MI, Díaz-Perales A, Blanca M,
Occupational asthma caused by IgE-mediated sensitization to multiple woods,
J Allergy Clin Immunol,
2012;129:254-256,
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(Plain text:
Campo P, Aranda A, Palacin A, Montanez MI, Diaz-Perales A, Blanca M,
Occupational asthma caused by IgE-mediated sensitization to multiple woods,
J Allergy Clin Immunol)
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Keywords: challenge, IgE, case report, carpenter, oa, rhinitis, Pine, Obeche (Triplochiton scleroxylon), Spain, Iroko (Milicia excelsa), cerejeira (Amburana cearensis),
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Abstract
We report a case of a multiple sensitization to different woods demonstrated by in vivo and in vitro tests. Cross-reactivity among different woods was assessed by using ELISA cross-inhibition assays. Surprisingly, pine extract was a strong inhibitor of 2 tropical woods such as obeche (genus Sterculia, family Sterculiaceae) and iroko (genus Milicia, family Moreaceae), which are unrelated to pine (genus Pinus, family Pineaceae). Information about wood allergens is scarce with few exceptions,1, 2 and so the nature of the allergen(s) responsible for the multiple sensitizations in this patient is still unknown; although the presence of low-molecular-weight compounds such as abietic acid and dehydroabietic acid was demonstrated in the extract by using gas chromatography combined with mass spectrometry, no IgE-binding activity was detected. Further studies are necessary to characterize wood antigens and develop standardized extracts to improve the diagnosis of occupational asthma caused by wood dust.
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