Occupational Asthma Reference

Yamashita M, Yamashita M, Tanaka J, Hirai H, Suzuki M, Kajigaya H, Toxicity of waterproofing spray is influenced by the mist particle size, Vet Hum Toxicol, 1997;39:332-334,

Keywords: waterproof spray, animal study, particle size, fluorocarbon, alveolitis

Known Authors

If you would like to become a known author and have your picture displayed along with your papers then please get in touch from the contact page. Known authors can choose to receive emails when their papers receive comments.


In a previous study, we showed that waterproofing sprays that are toxic generate mists with smaller particles than do nontoxic products. In this study, we made 4 waterproofing sprays (A, B, C and D) with identical ingredients but with different mist particle sizes and compared the pathological changes produced in the lungs of mice. The mist particle diameters were 32.8 +/- 3.2, 62.0 +/- 3.8, 89.1 +/- 4.1 and 143.2 +/- 5.0 microns for sprays A, B, C and D, respectively. Pathological lung changes were evaluated by a 6-criteria grading system (thickening of the alveolar septum, cellular infiltrations in the alveolar septum, alteration of the bronchial mucous membrane, hyperemia of the alveolar wall, transudative hemorrhage, and alveolar collapse). Sprays A and B caused significantly greater scores as compared to the control group for all the criteria except mucosal changes, whereas the changes from sprays C and D were slight and the differences in scores were not significant. These results suggest that toxicity of waterproofing spray is influenced by the mist particle size generated and may help manufacture safer waterproofing spray products

Full Text

Full text of this reference not available

Please Log In or Register to add the full text to this reference


Please sign in or register to add your thoughts.

Oasys and occupational asthma smoke logo