Occupational Asthma Reference

Palczynski C, Walusiak J, Krakowiak A, Halatek T, Ruta U, Krawczyk-Adamus P, Wittczak T, Swiercz R, Gorski P, Rydzynski K, Glutaraldehyde-induced occupational asthma: BALF components and BALF and serum Clara cell protein (CC16) changes due to specific inhalatory provocation test., Occup Med (London), 2005;55:572-574,

Keywords: Poland, challenge, glutaraldehyde, BAL, mechanism,

Known Authors

Pawel Gorski, University of Lodz, Poland Pawel Gorski

Jolanta Walusiak, Lodz Jolanta Walusiak

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65: Occup Med (Lond). 2005 Oct;55(7):572-4.

OBJECTIVES: The purpose of this study was to evaluate bronchoalveolar lavage fluid (BALF) components and Clara cell protein (CC16) concentration in serum and BALF in patients with glutaraldehyde (GA)-induced asthma, before and after a specific inhalatory provocation test (SIPT) with GA, in comparison to atopic asthmatics and healthy individuals.

METHODS: Spirometry and bronchoalveolar lavage were performed before and after SIPT. The serum and BALF concentrations of CC16 and cytogram content in BALF were evaluated.

RESULTS: In GA-sensitized asthmatics, the level of CC16 in BALF and serum was significantly lower at 24 h after SIPT in comparison with the values recorded prior to the experiment. There was a significant increase in the proportion of eosinophils, basophils and lymphocytes in BALF of GA-sensitized asthmatics obtained after SIPT.

CONCLUSIONS: The determination of CC16 either in serum or in BALF is a non-invasive test to detect Clara cell damage.

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