Occupational Asthma Reference

Krakowiak A, Krawczyk-Adamus P, Dudek W, Walusiak J, Palczynski C, Changes in cellular and biochemical profiles of induced sputum after allergen-induced asthmatic response: method for studying occupational allergic airway inflammation., Int J Occup Med Environ Health, 2005;18:27-33,

Keywords: induced sputum, eosinophilia, Poland, challenge

Known Authors

Jolanta Walusiak, Lodz Jolanta Walusiak

If you would like to become a known author and have your picture displayed along with your papers then please get in touch from the contact page. Known authors can choose to receive emails when their papers receive comments.


OBJECTIVES: The purpose of the study was to analyze morphological and biochemical changes in induced sputum after the provocation with occupational allergens (mixture of flours and grains) in subjects with diagnosed occupational asthma.

MATERIALS AND METHODS: Subjects with occupational asthma and healthy volunteers had physical examination, skin prick tests with common and occupational allergens, and spirometry. Specific IgE against common and occupational allergens was also measured. Bronchial inflammation was characterized by the percentage of cells, levels of eosinophil cationic protein (ECP), and changes in mucosal permeability index.

RESULTS: There was a significant increase in the proportion of eosinophils, basophils, lymphocytes, and in the ECP level in induced sputum of occupational allergics after the specific provocation.

CONCLUSION: Sputum induction is a reliable method for measuring allergen-induced airway inflammation.

Full Text

Full text of this reference not available

Please Log In or Register to add the full text to this reference


Please sign in or register to add your thoughts.

Oasys and occupational asthma smoke logo