Occupational Asthma Reference
|
Storaas T, Ardal L, Van Do T, Florvaag E, Steinsvåg SK, Irgens A, Aasen TB, Greiff L,
Nasal indices of eosinophilic and exudative inflammation in bakery-workers.,
IARC Scientific Publications,
2007;27:23-9,
|
|
(Plain text:
Storaas T, Ardal L, Van Do T, Florvaag E, Steinsvag SK, Irgens A, Aasen TB, Greiff L,
Nasal indices of eosinophilic and exudative inflammation in bakery-workers.,
IARC Scientific Publications)
|
Keywords: a 2-macroglobulin, airway, allergy, eosinophil cationic protein, flour, occupational rhinitis
Known Authors
If you would like to become a known author and have your picture displayed along with your papers then please get in touch from the contact page. Known authors can choose to receive emails when their papers receive comments.
Abstract
AIMS
Rhinitis symptoms frequently occur in bakery-workers. Yet, little is known about the pathophysiology of this condition. The objective of the present study was to examine nasal indices of inflammation in relation to occupational dust exposure, occupational rhinitis according to defined criteria, rhinitis symptoms associated to the workplace, and occupational sensitization in bakery-workers.
METHODS
Bakery-workers (n = 197) were subjected to interviews, questionnaires, workplace dust measurements, allergy tests, and nasal lavages with and without histamine. alpha(2)-Macroglobulin and eosinophil cationic protein (ECP) were measured in saline lavages as indices of plasma exudation and eosinophilic activity, respectively. Histamine lavages were employed to explore the nasal exudative responsiveness.
RESULTS
alpha(2)-Macroglobulin and ECP increased significantly by increased workplace dust exposure (P< or =0.035). Furthermore, the exudative responsiveness to histamine increased significantly by such exposure (P< or =0.016). Similar patterns were seen in workers with occupational rhinitis and in subjects with rhinitis symptoms associated to the workplace, but not in workers with occupational sensitization.
CONCLUSIONS
We conclude that occupational dust exposure in bakery-workers is associated with nasal eosinophilic exudative inflammation. In contrast, occupational sensitization is not a discriminating factor with regard to indices of eosinophilic, exudative inflammation in the present material.
Full Text
Comments
Please sign in or register to add your thoughts.