Occupational Asthma Reference

Burge PS, Single and serial measurements of lung function in the diagnosis of occupational asthma, Eur J Respir Dis Suppl, 1982;63:47-59,

Keywords: oa, TDI, peak flow, colophony, rodent, acrylate, pft, ps

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Sherwood Burge, Oasys Sherwood Burge

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Reports a different analysis of the Burge 1979 paper on 49 workers with a history of occupational asthma and 46 exposed controls. Sensitivity for expert interpretation against SIC showed a sensitivity of 77% for colophony sensitive electronics workers not taking prophylactic treatment and 100% for isocynate exposed printers. The colophony group had reduced sensitivity to 42% when taking prophylactic DSCG or beclomethasone. Specificity was 100% for colophony exposed workers and 83% for isocyanate exposed workers. FEV1, FVC and FEF75, FEF50 and FEF25 were measured before entry to the workplace and on leaving on a Monday, the next Friday and the following Monday after a 2 day absence from work. 22% of the cases and 11% of the controls had a fall in FEV1 after at least one of the 3 shifts. The coefficients of variation for FEF75, FEF50 and FEF25 were too high to allow meaningful pre-post shift comparisons.

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