Occupational Asthma Reference
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Leroyer C, Dewitte JD, Bassanets A, Boutoux M, Daniel C, Clavier J,
Occupational asthma due to chromium,
Respiration,
1998;65:403-405,
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Keywords: France, oa, chromium, construction, roofer, cement, challenge, rhinitis, potassium dichromate, dichromate, cr
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Abstract
We describe a 28-year-old subject employed as a roofer in a construction company since the age of 19, who developed work-related symptoms of a cough, shortness of breath, wheezing, rhinitis and headaches. A description of a usual day at work suggested that the symptoms worsened while he was sawing corrugated fiber cement. Baseline spirometry was normal, and there was a mild bronchial hyperresponsiveness to carbachol. A skin patch test to chromium was negative. A specific inhalation challenge showed a boderline fall in forced expiratory volume in 1 s (FEV1) after exposure to fiber cement dust. Exposure to nebulization of potassium dichromate (K2Cr2O7), at 0.1 mg.ml-1 for 30 min, was followed by an immediate fall by 20% FEV1. Simultaneously, a significant increase in bronchial hyperresponsiveness was demonstrated
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