Occupational Asthma Reference
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Armentia A, Lombardero M, Callejo A, Martin Santos JM, Gil FJ, Vega, J, Arranz ML, Martinez C,
Occupational asthma by Anisakis simplex,
J Allergy Clin Immunol,
1998;102:831-834,
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Keywords: Spain, oa, fish, challenge, IgE, Skin Tests, Anisakis simplex, new, food, nematode
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Abstract
BACKGROUND: No cases of occupational asthma caused by the inhalation of antigens from Anisakis simplex have been published.
OBJECTIVE: The purpose of this study was to evaluate the possibility that A simplex can play a role in the asthma experienced by 2 workers when handling fish and fish flour.
METHODS: Skin prick and bronchial challenge tests with A simplex were performed. We also carried out measurements of specific IgE to A simplex and immunoblotting.
RESULTS: Both patients had strong positive skin test responses, challenge test responses, and specific IgE to A simplex. Immunoblotting showed that both patients also had IgE against several bands in the fish flour extract, suggesting contamination by Anisakis allergens.
CONCLUSION: These 2 patients provide evidence for occupational asthma caused by A simplex, based on in vivo and in vitro tests for Anisakis-specific IgE
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