Occupational Asthma Reference

Hytonen M, Martimo KP, Estlander T, Tupasela O, Occupational IgE-mediated rhinitis caused by ninhydrin, Allergy, 1996;51:114-116,

Keywords: Finland, rhinitis, Ninhydrin, laboratory technician, paper, IgE, nc

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Abstract

Ninhydrin is a laboratory chemical used as a reagent in the detection of free amino and carboxyl groups in proteins and peptides. We present the case of a laboratory technician who developed symptoms of rhinitis when handling papers immersed in a solution containing ninhydrin. Prick tests for ninhydrin and ninhydrin RAST were positive. The inhalation provocation test in an exposure chamber gave an immediate nasal response. A positive prick test to ninhydrin, an elevated level of specific IgE antibodies to ninhydrin, and the RAST inhibition test confirmed an IgE-mediated type I allergic reaction. We are not aware of any other report of ninhydrin as a cause of IgE-mediated allergy

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