Occupational Asthma Reference

Wittczak T, Palczynski C, Szulc B, Gorski P, Bronchial asthma with inflammation of the nose mucous membrane induced by occupational exposure to methyl methacrylate in a dental technician, Medycyna Pracy, 1996;47:259-266,

Keywords: oa, methyl methacrylate, methacrylate, dental technician, nasal lavage, asthma, Female, history, Skin Tests, FEV1, eosinophil, ECP, causes

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Pawel Gorski, University of Lodz, Poland Pawel Gorski

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A case report of a 40-year-old female dental technician with a 13-year history of methyl methacrylate exposure is presented. Symptoms of dyspnea, wheezing, coughing and rhinorrhea occurred 6- 8 months after the first occupational contact with methyl-methacrylate containing substances. Skin tests performed with a battery of common allergens produced negative results. While performing a provocation test with methyl-methacrylate, the patient developed severe stridor and dyspnea with concomitant decrease in I second forced expiratory volume (FEV1) and peak respiratory flow (PEF). The increase in leukocytes, eosinophils, basophils, albumin, eosinophil cationic protein (ECP) and mast cell tryptase occurred in nasal lavage fluid after bronchial provocation test. The authors conclude that methyl-methacrylate may cause asthma (probably non-atopic) in persons occupationally exposed to its effect

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Please I need help. My PFTs were in the 40s and I have not worked around MMA since. That has been 8 months ago. I had pulmonary hypertension which my Dr. attributed to my asthma. I was switched to a different inhaler, stopped working in the Dental lab as a Denture Technician and now my Pulmonary pressures are normal and my asthma is in good control. My Pulmonary Doctor thinks the only way to know for sure if the MMA caused my problems is for me to go back to working with MMA but she doesn't believe that is wise she found a study from Yale about MMA that was inconclusive and I would like a case that is more solid. Are there any ?

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