Occupational Asthma Reference
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Lemiere C, Cartier A, Dolovich J, Malo JL,
Isolated late asthmatic reaction after exposure to a high-molecular-weight occupational agent, subtilisin,
Chest,
1996;110:823-824,
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Keywords: Canada, subtilisin, late reaction, FEV1, IgE, canada, challenge, skin prick test, healthcare, case report
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Abstract
High-molecular-weight agents generally induce immediate asthmatic reactions. We report the case of a subject who experienced a reaction that started after the first hour following exposure to subtilisin, a high-molecular-weight occupational agent. Any occurrence of immediate reaction was ruled out by measuring both FEV1 and lung volumes every 10 min in the first hour. This reaction was IgE-mediated as shown by immediate skin reactivity and increased specific IgE levels
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