Occupational Asthma Reference
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Stenton SC, Dennis JH, Hendrick DJ,
Occupational asthma due to ceftazidime,
Eur Respir J,
1995;8:1421-1423,
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Keywords: UK, oa, cephalosporin, antibiotic, br, ceftazidime
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Abstract
A worker employed in the manufacture of the new third generation cephalosporin antibiotic, ceftazidime, developed asthmatic symptoms, and a series of inhalation challenge tests was undertaken to investigate the problem. The inhalation of increasing daily doses of ceftazidime up to 3.2 mg, using a double-blind challenge protocol gave rise to symptoms, late asthmatic reactions, and increases in airway responsiveness to methacholine. A repeat challenge with the 3.2 mg dose additionally gave rise to a clear immediate reaction. Ceftazidime was, thus, shown to be capable of inducing occupational asthma
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