Occupational Asthma Reference

Stenton SC, Dennis JH, Hendrick DJ, Occupational asthma due to ceftazidime, Eur Respir J, 1995;8:1421-1423,

Keywords: UK, oa, cephalosporin, antibiotic, br, ceftazidime

Known Authors

Chris Stenton, Newcastle upon Tyne, UK Chris Stenton

David Hendrick, Newcastle-upon-Tyne David Hendrick

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A worker employed in the manufacture of the new third generation cephalosporin antibiotic, ceftazidime, developed asthmatic symptoms, and a series of inhalation challenge tests was undertaken to investigate the problem. The inhalation of increasing daily doses of ceftazidime up to 3.2 mg, using a double-blind challenge protocol gave rise to symptoms, late asthmatic reactions, and increases in airway responsiveness to methacholine. A repeat challenge with the 3.2 mg dose additionally gave rise to a clear immediate reaction. Ceftazidime was, thus, shown to be capable of inducing occupational asthma

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