Occupational Asthma Reference
|
O'Brien IM, NewmanTaylor AJ, Burge PS, Harries MG, Fawcett IW, Pepys J,
Toluene di-isocyanate-induced asthma. II. Inhalation challenge tests and bronchial reactivity studies,
Clin Allergy,
1979;9:7-15,
|
|
|
Keywords: oa, asthma, TDI, br, ch, HDI, MDI
Known Authors
If you would like to become a known author and have your picture displayed along with your papers then please get in touch from the contact page. Known authors can choose to receive emails when their papers receive comments.
Abstract
In sixty-three workers exposed to toluene di-isocyanate (TDI), no overall differences in bronchial reactivity to histamine inhalation and to exercise testing were found between the total groups of positive and negative TDI reactors to provocation tests. A subgroup of TDI highly sensitive subjects reacting to very low concentrations (less than or equal to 0.001 p.p.m.) were more sensitive to both histamine and exercise than the group who were less sensitive to TDI, and who reacted to higher concentrations (0.002--0.02 p.p.m.) than the group of non-reactors. There were, however, in the last group a number of subjects with high degrees of histamine reactivity who did not react to the TDI. These findings suggest that, on the one hand, the asthmatic reactions to TDI cannot be attributed solely to non-specific mechanisms and, on the other, that in subjects with high degrees of specific sensitivity non-specific mechanisms may also be playing a part
Full Text
Full text of this reference not available
Please Log In or Register to add the full text to this reference
Comments
Please sign in or register to add your thoughts.