Occupational Asthma Reference

Malo JL, Ouimet G, Cartier A, Levitz D, Zeiss CR, Combined alveolitis and asthma due to hexamethylene diisocyanate (HDI) with demonstration of crossed respiratory and immunologic reactivities to diphenylmethane diisocyanate (MDI), J Allergy Clin Immunol, 1972;72:413-419,

Keywords: asthma, HDI, MDI, oa, as , alveolitis, ch, xr, isocyanate, br, IgG

Known Authors

André Cartier, Hôpital de Sacré Coeur, Montreal, Quebec, Canada André Cartier

Jean-Luc Malo, Hôpital de Sacré Coeur, Montreal, Quebec, Canada Jean-Luc Malo

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A worker exposed intermittently to hexamethylene diisocyanate (HDI) developed episodes of dyspnea, wheezing, and fever on working days. Complete lung function tests performed when the subject was asymptomatic were normal except for increased airway responsiveness to histamine, which significantly improved after a 3 wk period off work. At that time, specific inhalation challenges with HDI were carried out. After being exposed for 5 min, the subject developed general malaise, cough, fever, and leukocytosis, together with a mixed restrictive and obstructive breathing defect. We demonstrated a subsequent increase in airway hyperexcitability, which lasted for 2 mo. The subject was also challenged with diphenylmethane diisocyanate (MDI) for 15 min. A late obstructive reaction was documented. Increased levels of specific IgG antibodies against HDI-human serum albumin (HSA) and MDI-HSA were demonstrated.

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