Occupational Asthma Reference

Kane GC, Marx JJ, Prince DS, Hypersensitivity pneumonitis secondary to Klebsiella oxytoca. A new cause of humidifier lung, Chest, 1993;104:627-629,

Keywords: alveolitis, new, non-occupational, humidifier, home, humidifier fever, bal, IgG, woman, fever, cough, diagnosis, water, causes, cold

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A 30-year-old woman developed recurrent episodes of fever, dyspnea, and nonproductive cough after repeated exposure to a home humidifier. The diagnosis of hypersensitivity pneumonitis was confirmed by detection of serum-binding antibodies at significant titer to Klebsiella oxytoca colonizing the humidifier water but not to other potential antigens. This represents a newly recognized cause of hypersensitivity pneumonitis related to exposure to K oxytoca contaminating a commercially available ultrasonic cold air home humidifier. The potential role for these frequently used home humidifier devices in unexplained pulmonary illness is emphasized. The cause is only infered from the precipitins, no challenge

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