Occupational Asthma Reference
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Kraut A, Peng Z, Becker AB, Warren CP,
Christmas candy maker's asthma. IgG4-mediated pectin allergy,
Chest,
1992;102:1605-1607,
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Keywords: oa, pectin, nc, ch, IgE, IgG4, food, case report
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Abstract
We evaluated a 29-year-old candy maker with no history of asthma who developed asthma after exposure to pectin, a compound manufactured from fruits and fruit rinds. Following eight years of employment during which he added pectin to a recipe for Christmas candies, the candymaker developed acute respiratory symptoms. Challenge testing with the pectin mixture caused a 40 percent decrease in FEV1. Skin prick testing was positive to the pectin extract. Total IgE was normal and pectin-specific IgE antibodies were not detected. A strongly positive pectin-specific IgG4 antibody response was present that was not detected in a control serum and could be inhibited by the addition of pectin. Antigen-specific IgG4 should be sought in IgE negative cases of occupational asthma
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