Occupational Asthma Reference
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Pezzini A, Riviera A, Paggiaro PL, Spiazzi A, Gerosa F, Filieri M, Toma G, Tridente G,
Specific IgE antibodies in twenty-eight workers with di-isocyanate-induced bronchial asthma,
Clin Allergy,
1984;14:453-461,
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Keywords: oa, IgE, as , isocyanate, TDI, MDI, ch, se
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Abstract
A specific IgE-mediated response was evaluated in twenty-eight workers exposed to TDI or MDI, with diagnosis of occupational asthma and positive to bronchial provocative challenge. The presence of anti-diisocyanate IgE was observed in 27% of subjects exposed to TDI and 83% of those exposed to MDI, particularly in individuals who experienced an acute massive exposure. An immediate-type response to bronchial provocative test was found in 66% of individuals with specific antibodies. Specific IgE are prevalent (91%) in subjects who developed symptoms before 6 years of exposure to isocyanates. The results suggest an association between the presence of specific IgE, early asthmatic symptoms and heavy episodic exposure.
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