Occupational Asthma Reference

O'Brien IM, Bull J, Creamer B, Sepulveda R, Harries MG, Burge PS, Pepys J, Asthma and extrinsic allergic alveolitis due to Merulius lacrymans, Clin Allergy, 1978;8:535-542,

Keywords: oa, alveolitis, as , Merulius lacrymans, nc, IgG, IgE, ch, home, non-occupational

Known Authors

Sherwood Burge, Oasys Sherwood Burge

Jack Pepys, Royal Brompton Hospital Jack Pepys

Mark Harries, Brompton Hospital and Northwick Park Mark Harries

R Sepulveda, Santiago, Chile R Sepulveda

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A teacher with breathlessness of insidious onset developed acute symptoms on return home following his discharge from hospital. His flat was found to have extensive dry rot (Merulius lacrymans). Precipitins and specific IgE and IgG antibody against M. lacrymans were present and intracutaneous testing gave a typical dual skin reaction. Pulmonary physiology demonstrated airflow obstruction with a low DLCO and KCO, and a chest X-ray showed diffuse micronodular shadowing, maximal in the mid-zones. Inhalation challenge testing provoked a combined asthmatic reaction without a change in DLCO. Rapid clinical recovery and more gradual radiographic and physiological improvement followed cessation of exposure to the antigen.

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