Occupational Asthma Reference
|
Hargreave FE, Ryan G, Thomson NC, OByrne PM, Latimer K, Juniper EF, Dolovich J,
Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance,
J Allergy Clin Immunol,
1981;68:347-355,
|
|
|
Keywords: nsbr, method, key, methacholine, Canada
Known Authors
If you would like to become a known author and have your picture displayed along with your papers then please get in touch from the contact page. Known authors can choose to receive emails when their papers receive comments.
Abstract
Bronchial responsiveness is the term used to de- scribe the tendency of the airways to bronchoconstrict to specific stimuli such as allergens and isocyanates, which select a limited population of apparently sen- sitized subjects, and to nonspecific (nonallergic) stim- uli, which affect most asthmatic persons. Specific bronchial responsiveness to allergic stimuli is difficult to quantitate because commonly available allergen ex- tracts are not well standardized for the number and concentration of components. Nonspecific respon- siveness can be quantitated by inhalation tests with histamine or methacholine, by exercise, or by iso- capnic hyperventilation of cold air, and may be in- creased in asthma and other conditions such as chronic obstructive bronchitis and cystic fibrosis. In this article we will discuss the measurement of nonspecific bron- chial responsiveness by inhalation tests with histamine or methacholine and its relationship to the occurrence and severity of asthma.
METHODS
Full Text
Comments
Please sign in or register to add your thoughts.