Occupational Asthma Reference
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Mason P, Scarpa, MC, Liviero F, Guarnieri G, Maestrelli,P,
Distinct Clinical Phenotypes of Occupational Asthma due to Diisocyanates,
J Occup Environ Med,
2017;59:539-542,doi: 10.1097/JOM.0000000000001017
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Keywords: Isocyanate, Italy, phenotype, challenge, OA,
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Abstract
Objective:
To assess whether diisocyanate occupational asthma represents a unique phenotype.
Methods:
We studied 187 patients with diagnosis of asthma due to diisocyanates confirmed by a positive specific inhalation challenge. The simplified algorithm from severe asthma research program (SARP) (Moore et al, 2010) was applied to classify patients into five clusters.
Results:
Our patients were allocated in three of the five clusters described in common asthma, since the most severe Clusters (4 and 5) were not represented. Cluster 2 was the most populated, as in common asthma, and included the youngest patients with the shortest duration of exposure to the sensitizers. Cluster 3 included older men patients with worse lung function and longer occupational exposure.
Conclusions:
Diisocyanate asthma is a heterogeneous disease. Differences across clusters include demographic characteristics, lung function, and chronology of diisocyanate exposure.
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