Occupational Asthma Reference
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Ye YM, Choi GS, Park HJ, Kim HA, Hur GY, Park HS,
Occupational Asthma due to Styrene and Toluene Diisocyanate,
Korean J Asthma Allergy Clin Immunol,
2007;27:70-73,
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Keywords: oa, styrene, korea, automotive repair, isocyanate, TDI, nsbr, SIC, dual response, sputum eosinophilia, induced sputum,
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Abstract
Styrene, a common solvent and volatile organic compound (VOC), is widely used in the factories of plastics, resins, insulators, coatings, and paints. While toluene diisocyanate (TDI) is a well-known causative agent of asthma, styrene has been rarely reported to cause occupational asthma (OA). We report a 50-year-old repairman with OA due to both styrene and TDI in whose job was filling cracks and flattening the surface of vehicles with styrene-containing plaster's putty, followed by spray painting. He suffered from cough, dyspnea durings the work with putty. Hepresented with a 2-year history of asthma and allergic rhinitis. The level of serum total IgE and sputum eosinophils were 2,878 IU/L and 63%, respectively. The methacholine challenge test was positive (PC20 0.59 mg/mL). The bronchoprovacation tests with TDI and styrene showed early and dual responses, respectively. Currently, he is in well- controlled state with the use of a combination of inhaled corticosteroid and long acting beta2-agonist after the avoidance of the causative agents.
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