Gene-environment interactions identified in cleaners and healthcare workers with occupational asthma.

Exposure alone does not account for susceptibility to develop occupational asthma, and gene-environment interactions are likely to be involved (as well as other factors such as smoking and any possible high-dose tolerance). Data from three large European cohorts: EGEA, SAPALDIA, and ECRHS used a candidate pathway-based strategy to identify 163 genes involved in response to oxidative stress and potentially related with exposures in cleaners and healthcare workers. Eight SNP by exposure interactions at five loci were found at p<0.005: PLA2G4A (rs932476, chromosome 1), near PLA2R1 (rs2667026, chromosome 2), near RELA (rs931127, rs7949980, chromosome 11), PRKD1 (rs1958980, rs11847351, rs1958987, chromosome 14), and PRKCA (rs6504453, chromosome 17). Results were consistent across the three studies and after accounting for smoking.

References

	Rava M, Ahmed I, Kogevinas M, Le Moual N, Bouzigon E, Curjuric I, Dizier MH, Dumas O, Gonzalez JR, Imboden M, Mehta AJ, Tubert-Bitter P, Zock JP, Jarvis D, Probst-Hensch NM, Demenais F, Nadif R., Genes Interacting with Occupational Exposures to Low Molecular Weight Agents and Irritants on Adult-Onset Asthma in Three European Studies, Environ Health Perspect, 2016;:,10.1289/EHP376

Comments

Exposure alone does not account for susceptibility to develop occupational asthma, and gene-environment interactions are likely to be involved (as well as other factors such as smoking and any possible high-dose tolerance). Data from three large European cohorts: EGEA, SAPALDIA, and ECRHS used a candidate pathway-based strategy to identify 163 genes involved in response to oxidative stress and potentially related with exposures in cleaners and healthcare workers. Eight SNP by exposure interactions at five loci were found at p<0.005: PLA2G4A (rs932476, chromosome 1), near PLA2R1 (rs2667026, chromosome 2), near RELA (rs931127, rs7949980, chromosome 11), PRKD1 (rs1958980, rs11847351, rs1958987, chromosome 14), and PRKCA (rs6504453, chromosome 17). Results were consistent across the three studies and after accounting for smoking.

8/1/2018