Why do workers with the highest exposure to laboratory animals have less disease than those with intermediate exposure?

Results from a cross-sectional study of laboratory animal workers exposed to rats showed that IgG and IgG4 antibodies to rat urinary protein reduced specific IgE binding to B cells, perhaps explaining the U shaped dose-response curve seen in cross-sectional studies, where those with the highest exposures have relatively less disease.

References

	Jones M, Jeal H, Schofield S, Harris JM, Shamji MH, Francis JN, Durham SR, Cullinan P, Rat-specific IgG and IgG4 antibodies associated with inhibition of IgE–allergen complex binding in laboratory animal workers, Occup Environ Med, 2014;71:619-623,10.1136/oemed-2014-102119

Comments