This is a meta-analysis of individual-level data, collected between 1985 and 2010, from 102 175 working-age men and women in 11 prospective European studies. Job strain (a combination of high demands and low control at work) was self-reported at baseline. Incident severe asthma exacerbations were ascertained from national hospitalization and death registries. During a median follow-up of 10 years, 1 109 individuals experienced a severe asthma exacerbation. After adjustment for potential confounders no association was observed in the analyses with asthma defined using any diagnostic code (HR: 1.01, 95% CI: 0.86, 1.19). Conclusions; job strain is probably not an important risk factor for severe asthma exacerbations leading to hospitalization or death.