What is the shortest latency for isocyanates
A patient developed severe allergic asthma within days of exposure to low levels of isocyanates in a foam factory. Re-exposure at the factory caused recurrence within days. He had a marked eosinophillic reaction which recovered
He has been left with asthma
The exposure did not suggest a RADS type reaction
He denies any pre exposure
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2-week latency has been described, or sensitisation after a single large exposure (as opposed to an irritant reaction with no subsequent sensitisation). If the latency is very short you always have to think about previous sensitisation in another workplace. It sometimes takes a few days/weeks for work-related symptoms to recur in these circumstances.
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