Ninhdrin as a cause of occupational asthma?
I currently have a patient that I see in clinic who has suspected occupational asthma. Their job involves counting money that has been dusted for fingerprints with ninhydrin (1,2,3-Indantrione hydrate).
Peak flow readings are suggestive of occupational asthma, has anyone had a similar case with this? I've seen one case report in ERJ but can't see anything else in the literature.
Is it worth referring for further tests?
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There is an obsure reference to a paper to which I dont have access which reads
"The diagnosis of contact urticaria to latex is difficult: many patients suspected the glove powder (such as case 5), but this aetiology cannot hold when skin tests with natural latex or RAST to latex are positive. The hypothesis that the allergen may be water-soluble proteins is supported by
numerous observations. The water-soluble substances obtained after maintaining latex in water give positive skin test and a positive reaction to ninhydrin; cyanogen bromide-activated discs used for coating allergen can only bind proteinss,6 in the RAST technique"
The refernce quoted is Wrangsjö K, Mellström G, Axelsson G , Discomfort from rubber gloves indicating contact urticaria , Contact Dermatitis , 1986 ; 15 : 79-84
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There is also a case of rhinitis and asthma developing as a result of occupational exposure
Eur Respir J. 1997 Aug;10(8):1918-21.
Rhinitis caused by ninhydrin develops into occupational asthma.
Piirilä P1, Estlander T, Hytönen M, Keskinen H, Tupasela O, Tuppurainen M.
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