What is the deffinition that you use to determine LMW vs. HMW?
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Is is 10,000 Da or 1,000 Da or what is the cutting off point that says anything over this is HMW and anything under is LMW?
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There is no clear cut-off between high and low MW agents. High MW agents are usually classified as those sufficiently large to act as antigens on their own (i.e. without requiring conjugation to a carrier). This applies to most biological agents.
Anything under 1000 daltons would definately be a low molecular weight agent, even if biologically derived, such as the resins from various trees (e.g. colophony, podocarpic acid and plicatic acid). There is clearly a grey area in between.
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