Reference

Hudson P, Cartier A, Pineau L, Lafrance M, St Aubin JJ, Dubois JV, Malo JL, Follow-up of occupational asthma caused by crab and various agents, J Allergy Clin Immunol, 1985;76:682-688,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

63 subjects studied after cessation of exposure (>60months), 49 of whom are still symptomatic. The symptomatic subjects had history of more prolonged exposure after onset of symptoms as compared to respective asymptomatic group. Authors infer that the nature of the product responsible for the reaction may play a role and also the type of asthmatic reaction documented at the time of diagnosis through specific inhalation challenge could influence the prognosis. Conclude that subjects with occupational asthma caused by various agents can remain symptomatic of asthma and demonstrate a persistence of bronchial obstruction and hyper-excitability for prolonged periods after cessation of exposure.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

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The symptoms and functional impairment of occupational asthma caused by various agents may persist for many years after avoidance of further exposure to the causative agent.

The likelihood of improvement or resolution of symptoms or of preventing deterioration is greater in workers who have shorter duration of symptoms prior to avoidance of exposure.

Non Bohrf Information

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