Reference

Cartier A, Grammer L, Malo JL et al, Specific Serum Antibodies Against Isocyanates: Association With Occupational Asthma, J Allergy Clin Immunol, 1989;84:507-514,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

The sera of 62/65 workers referred for specific inhalation challenges (SIC) with isocyanates were analysed for the presence of specific antibodies to the relevant isocyanate. SIC were positive in 29 subjects, and were more often positive in those subjects with increased non-specific bronchial responsiveness. 29 subjects demonstrated increased levels of specific IgE and/or IgG antibodies to isocyanates in the absence of antibodies against human serum albumin. Although there was a loose association between the results of SIC and levels of specific IgE, the association was much better with the level of specific IgG. 21/29 subjects (72%) with positive challenges had increased levels of specific IgG, whereas 25/33 subjects (76%) with negative challenges had normal levels of antibodies.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

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A large number of concordant studies from different centres using different methodologies demonstrated that increased non-specific reactivity is often found in workers with occupational asthma. There are however many reports of normal methacholine or histamine reactivity within 24 hours of exposure in workers with confirmed occupational asthma.

Non Bohrf Information

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