Reference

Weill H, Waddell LC, Ziskind M, A study of workers exposed to detergent enzymes, JAMA, 1971;26:425-433,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

13/60 had symptoms of 'lower respiratory tract disease,' 11 with wheezing, cough, shortness of breath and chest tightness. No relation between smoking and symptoms of exposure level and symptoms was observed. Symptomatic individuals were more likely to have an atopic history - 43% of symptomatic individuals were atopic versus 19% of asymptomatic individuals. In plant A, no positive skin prick tests were found in the low exposure group versus 53% of the moderate exposure group and 45% in the high exposure group. In plant B, 16% positive skin prick test reactions were found in the low exposure group, versus 35% of the moderate exposure group and 52% in the high exposure group.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

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The risk of sensitisation and occupational asthma is increased by higher exposures to many workplace agents.

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Atopy increases the risk of developing occupational asthma caused by exposure to many high molecular weight agents that induce the production of specific IgE antibodies.

Non Bohrf Information

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