Reference

Beghe B, Padoan M, Moss CT et al, Lack of association of HLA class I genes and TNF alpha-308 polymorphism in toluene di-isocyanate-induced asthma, Allergy, 2004;59:61-64,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Study aimed to investigate the role of genetic factors in the development of toluene di-isocyanate (TDI)-induced asthma. The distribution of human leukocyte antigen (HLA) class I genes and of tumour necrosis factor (TNF)-alpha A-308G polymorphism was analysed in 142 patients with TDI-induced asthma and in 50 asymptomatic exposed subjects. Neither the distribution of HLA class I antigens nor the distribution of TNF-alpha A-308G polymorphism was different between patients with TDI-induced asthma and asymptomatic exposed subjects suggesting that HLA class I antigens and TNF-alpha A-308G are not associated with susceptibility or resistance to the development of TDI-induced asthma.

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