BOHRF Original Authors' Main Conclusions
The original authors' main conclusions are taken from Abstract, Results and
Discussion. They are decided upon by the authors of the BOHRF occupational
asthma guidelines and form part of the guidelines.
Study aimed to characterize effects of di-isocyanate exposures on auto body shop workers. No overt cases of clinically apparent di-isocyanate asthma were identified based on spirometry, methacholine challenge, peak flows, and symptoms. Hexamethylene di-isocyanate (HDI)-specific lymphocyte proliferation was present in 30% and HDI-specific IgG in 34% of workers, but they were not associated. HDI-specific IgE was detected in 2 workers. HDI-specific lymphocyte proliferation, increased methacholine responsiveness, and symptoms of chest tightness/ shortness of breath were more common in most heavily HDI-exposed workers. Findings demonstrate the presence of HDI-specific immune responses in a large proportion of healthy HDI-exposed workers.
BOHRF Associated Evidence Statements
The BOHRF occupational asthma guidelines state that this reference is associated
with the following evidence statements
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