Reference

Park HS, Nahm DH, Prognostic factors for toluene di-isocyanate-induced occupational asthma after removal from exposure, Clin Exp Allergy, 1997;27:1145-1150,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Subjects were given anti-asthmatics, recommended to avoid exposure to Toluene di-isocyanate (TDI), and were monitored for 2 years (mean follow-up 12 months). 17/35 recovered completely, 11 showed significant improvement and 7 remained stable. No effect of age or exposure duration or specific IGE was noted. Favourable prognosis was associated with short duration of asthmatic symptoms before diagnosis, immediate cessation of exposure after diagnosis, milder degree of airway hyper-responsiveness, and the presence of specific IgE antibodies to TDI-human serum albumin conjugate.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

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2+

The likelihood of improvement or resolution of symptoms or of preventing deterioration is greater in workers who have relatively normal lung function at the time of diagnosis.

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2+

The likelihood of improvement or resolution of symptoms or of preventing deterioration is greater in workers who have shorter duration of symptoms prior to diagnosis.

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2+

The likelihood of improvement or resolution of symptoms or of preventing deterioration is greater in workers who have shorter duration of symptoms prior to avoidance of exposure.