Reference

Padoan M, Pozzato V, Simoni M et al, Long-term follow-up of toluene di-isocyanate-induced asthma, Eur Respir J, 2003;21:637-640,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Followed up on average 11 years after removal from exposure. Symptoms occurred in 84.6% of subjects still exposed to Toluene di-isocyanate (TDI) and 75% of those removed for < 10years and in 60% of those removed for > 10years. Confirms the poor clinical outcome of TDI-induced asthma. Symptoms and airway hyper-responsiveness improve slowly for >10 years after leaving the workplace. A more favourable prognosis was associated with a better lung function, a lower degree of airway hyper-responsiveness to methacholine at diagnosis and longer interval from cessation of exposure.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

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The symptoms and functional impairment of occupational asthma caused by various agents may persist for many years after avoidance of further exposure to the causative agent.

The likelihood of improvement or resolution of symptoms or of preventing deterioration is greater in workers who have relatively normal lung function at the time of diagnosis.

Non Bohrf Information

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