Reference

Moscato G, Dellabianca A, Vinci G et al, Toluene Di-isocyanate-Induced Asthma : Clinical Findings And Bronchial Responsiveness Studies In 113 Exposed Subjects With Work-Related Respiratory Symptoms, J Occup Med, 1991;33:720-725,

BOHRF Original Authors' Main Conclusions

The original authors' main conclusions are taken from Abstract, Results and Discussion. They are decided upon by the authors of the BOHRF occupational asthma guidelines and form part of the guidelines.

Study reports the clinical findings and results of inhalation challenge with toluene di-isocyanate (TDI) and methacholine in 113 subjects with a history of exposure to TDI and work-related respiratory symptoms. Only some of the subjects (40.7%) had isocyanate asthma, diagnosed by a positive TDI inhalation challenge. Most reactors had a dual (30.4%) or a late (41.3%) response and the interval between the last occupational exposure and the specific challenge was significantly shorter in reactors. They also had a significantly higher proportion of positive responses to methacholine and a significantly lower mean PD15 FEV1. Authors conclude that methacholine challenge could not identify subjects with TDI- asthma.

BOHRF Associated Evidence Statements

The BOHRF occupational asthma guidelines state that this reference is associated with the following evidence statements

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A large number of concordant studies from different centres using different methodologies demonstrated that increased non-specific reactivity is often found in workers with occupational asthma. There are however many reports of normal methacholine or histamine reactivity within 24 hours of exposure in workers with confirmed occupational asthma.

Non Bohrf Information

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